<h4>Aim</h4>To assess the prognostic role of admission C-reactive protein (CRP) in patients with acute aortic dissection (AAD).<h4>Methods</h4>We searched Medline and Scopus for studies published before January 2019 that evaluated the prognostic impact of CRP on all-cause mortality during short- and mid-term follow-up period in patients with AAD. This evidence concerns the gene CRP and Aortic dissection.