Likewise, in a model of acute myeloid leukemia induced by co‐expression of the AML1/ETO9a (AE9) fusion oncoprotein and oncogenic NrasG12D (Nras) (Zuber et al, 2009), we observed fast malignant transformation of p53EE/EE hematopoietic stem cells (HSCs) and disease progression. This evidence concerns the gene RUNX1 and acute myeloid leukemia.