Unlike what has been reported for the p53 hot‐spot mutants R172H or R270H, we did not observe an increase in metastatic tumors in p53EE/EE and p53EE/− compared to p53−/− and p53+/− mice (Appendix Table S1), suggesting a lack of GOF properties of the EE mutant. This evidence concerns the gene TP53 and metastatic neoplasm.