In a study on the EPIC-Italy cohort and the MCCS cohort, hypomethylation of six CpG sites was associated with smoking and lung cancer risk: cg05575921 in the AHRR (aryl-hydrocarbon receptor repressor) gene; cg03636183 in the F2RL3 (F2R-like thrombin/trypsin receptor 3) gene; cg21566642 and cg05951221 in 2q37.1; cg06126421 in 6p21.33; and cg23387569 in 12q14.1. The gene discussed is F2RL3; the disease is lung carcinoma.