Oxidative stress in the heart is an essential causal agent of hypertension, activating intracellular signalling that induces heart dysfunction through apoptosis or cell overgrowth.10,35 We found higher left-ventricle TBARS levels and lower catalase activity in 2K1C-St rats than in Sham (St and EE) rats. The gene discussed is CAT; the disease is Hypertension.