TGFB1 and cancer: The results of a seminal study show that activation of the protein tyrosine phosphatase Pez in combination with TGFβ signaling significantly silences both the miR-200 superfamily and miR-205 (50) At the same time, when different human cancer cell lines are stratified according to the levels of epithelial (high in E-cadherin) and mesenchymal (high in vimentin) gene signatures, the miRNA signature of the mesenchymal-phenotype cancers show strong downregulation of the miR-200 family (51).