SERPINE1 and Stroke: It consists of adhesive glycoproteins, which play a key role in the regulation of processes such as platelet adhesion, aggregation and clotting, via binding to integrin, plasminogen activator inhibitor (PAI-1), urokinase plasminogen activator receptor (UPAR), and heparin.9,10 In spite of that fact, plasma VN levels were significantly increased in patients with CAD, also showing a positive correlation with severity of the disease.11 Notably, PAI-1 has been recognized as a central molecule linked to pathogenesis and progression of thrombotic vascular events, including stroke.