The fatty acids released in the circulation, in turn, inhibit the anti-lipolytic action of insulin and promote higher lipid absorption by the liver, leading to dyslipidemia and hepatic steatosis.3,32,33 Hamsters on a 10-week hyperlipidemic diet containing cholesterol (0.2%) developed dyslipidemia and hepatic steatosis, with impaired TC, TG, LDL-c, ALT, and AST serum concentrations.34 Liver histopathological analysis of Sprague-Dawley rats fed a high-cholesterol diet (1.5%) also revealed hepatic steatosis and inflammation.35 This evidence concerns the gene INS and fatty liver disease.