Figure 1E shows representative EPM tracks of control and KO mice. Consistent with the OFT results, mice lacking Ano2 showed significantly greater open-arm exploration (Two-way ANOVA in (F), p=0.0042; Mann Whitney test in (G), p=0.0002 n=26 for KO and n = 23 for control), reflecting a reduction in anxiety-related behaviors as compared to control littermates (Figure 1F,G). As in the case of OFT tests, the total distance traveled by Ano2 KO mice and their control littermates were comparable (Figure 1H). Here, ANO2 is linked to Anxiety.