F7 and hyperinsulinemic hypoglycemia, familial, 4: The second prevalent disease allele in the dataset was the rs36209567 variant in the factor VII (F7, MIM#613878) gene (gnomAD NFE AF = 0.001, p = .001), a mutation responsible for factor VII deficiency, a disorder that is extremely rare in general population (1:500,000, according to Wulff & Herrmann, 2000).