On the one hand, the CXCR3 chemokines, especially CXCL9 and CXCL10, facilitate the recruitment of CXCR3-positive Th1, NK, and NKT cells as well as cytotoxic T lymphocytes to the tumor microenvironment, which trigger the development of a tumor-suppressive immune milieu [46, 62, 63]. Here, CXCR3 is linked to neoplasm.