Since levels of IGFBP‐4 were significantly lower in SSc lung fibroblasts compared to control fibroblasts (Figure 3A) and IGFBP‐4 reduces CXCR4 while IGFBP‐4 deficiency increases CXCR4 levels (Figure 5A‐C), higher levels of CXCR4 in SSc patient lung fibroblasts may be due to reduced IGFBP‐4 levels. The gene discussed is CXCR4; the disease is systemic sclerosis.