Phosphorylation levels of TRBP are induced in obese livers when PKR is activated, and inactivation of hepatic TRBP in ob/ob obese mice results in a significant reduction of JNK activity and eIF2α phosphorylation, which coincides with the alleviation of systemic glucose intolerance, insulin resistance, and hepatic steatosis (147). The gene discussed is EIF2AK2; the disease is Hepatic steatosis.