Subsequently, reports indicate that FTO demethylates not only m6A, but also N6,2′-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), and regulate RNA stability (14, 15), with findings that further support the concept of RNA modification's role in the pathogenesis of obesity. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.