For example, phosphorylation of RPN6 increases proteasome activity and seems a very promising target to improve protein degradation in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) (Lokireddy et al., 2015; VerPlank et al., 2019). The gene discussed is PSMD11; the disease is early-onset autosomal dominant Alzheimer disease.