Multivariable analysis adjusted for covariates indicated that only elevated serum CEA level (>4 ng/ml) was predictive of worst survival with risk of death of 4.364 (95% CI: 1.356–14.050— p = 0.014), while previous extrathoracic metastasectomy (R.R.: 3.028, 95% CI: 1.091–8.406— p = 0.033), PET positivity (R.R.: 2.702, 95% CI: 1.041–7.013— p = 0.041) and DFI > 12 months (R.R.: 0.137, 95% CI: 0.054–0.346—p < 0.001) between CRC and first detection of LM confirmed to be predictive factor of recurrence. The gene discussed is CEACAM5; the disease is colorectal carcinoma.