Overweight and obesity are clearly associated with alterations in the lipid profile and raise in the markers of systemic inflammation, including C-reactive protein (CRP) and proinflammatory cytokines, such as interleukin- (IL-) 1 beta (IL-1β), IL-6, and tumor necrosis factor alpha (TNF-α) [2, 3]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.