Expectedly, IL-25 deletion under WT or Tpl2-KO background both dramatically increased the mortality rate of FH mice, and suppressed the expression of MDSC-recruiting chemokine genes Cxcl1 and Cxcl2 in P. acnes-primed livers (Figures 7B,C), implying IL-25 is also critical for the liver recruitment of MDSC and thus protect against P. acnes/LPS-induced FH. This evidence concerns the gene MAP3K8 and familial hyperaldosteronism.