In addition, during P. acnes/LPS-induced FH pathogenesis, Tpl2 seemed specifically mediate IL-25-induced expression of CXCL1/2, but not affected the induction of CCL17, a previously reported MDSC-attracting chemokine that could be induced by IL-25 administration in D-Gal/LPS-induced FH mice (15), suggesting Tpl2 modulated IL-25-induced chemokine expression in a context-dependent manner. The gene discussed is CXCL1; the disease is familial hyperaldosteronism.