To figure out which type of cells in vivo was directly targeted by Tpl2 to protect against FH-induced liver failure, we generated the mixed bone marrow (BM) chimeric mice by reconstituting the lethally irradiated WT mice with WT or Tpl2-deficient BM, which were then challenged with P. acnes/LPS to induce FH. Here, MAP3K8 is linked to liver failure.