Interestingly, Tpl2/Il25 double knockout mice didn't further exaggerated the disease severity of P. acnes/LPS-induced FH when compared with Tpl2-deficient mice, as reflected by comparable mortality rate of these two strains of FH mice (Figure 7B), suggesting Tpl2-mediated prevention of FH is indeed through IL-25 signaling. The gene discussed is MAP3K8; the disease is familial hyperaldosteronism.