Although no AhR corepressor has been identified to date, some evidence has been provided for the presence of coactivators in the enhancesome of AhR—namely, steroid receptor coactivator 1 (SRC-1), NCOA2 (also belonging to the SRC family), and p/CIP—all of which increase TCDD-dependent expression of a XRE-driven reporter gene in hepatoma cells (62). This evidence concerns the gene SRC and hepatocellular carcinoma.