CD8A and breast carcinoma: Importantly, CD8 T lymphocytes have been purposed as players in the promotion of aggressive features in breast cancer tumorigenesis (129); but using CD8 T cells as therapeutic targets implicates affecting one of the most important defenses toward infections, so research about the regulatory networks underlying T cell polarization in dynamic feedback with epithelial cells open new opportunities for the development of more precise therapies by simulating multiple or all the possible perturbations in an integral network as also suggested for breast cancer therapy (130).