ALB and Hyperglycemia: [Deformability]- Impaired deformability in T2DM- Hyperglycemia-induced glycation and oxidation (Resmi et al., 2005)- formation of advanced glycation end-products (AGEs) including HbA1c- increased internal fluid viscosity & reduced membrane fluidity (Watala et al., 1985; Linderkamp et al., 1999)[Aggregation]- Increased aggregation in T2DM- reduced charges in RBC membrane (sialic acid moieties of glycoproteins)- increased fibrinogen level and decreased albumin in T2DM lead to synergistic increase of RBC aggregation- (Angelkort, 1999; Vayá et al., 2011; Li et al., 2015; Mahendra et al., 2015)