Among the late-onset AD patients, there have been known mixed pathologies in the brain such as TDP-43, argyrophilic grain disease (Ferrer et al., 2008; Landau et al., 2016), aging-related tau astrogliopathy, or hippocampal sclerosis (Nelson et al., 2011; Cairns et al., 2015). This evidence concerns the gene TARDBP and Alzheimer disease.