Recent studies have shown that tau PET tracers such as 18F-THK5351 and 18F-AV-1451 significantly differentiate AD patients from old adults with normal cognition, reflect disease progression in AD, and correlates with neurofibrillary tangle retention (Cho et al., 2016; Schwarz et al., 2016; Schöll et al., 2016; Kang et al., 2017). Here, MAPT is linked to Alzheimer disease.