MAPT and Alzheimer disease: Autopsy studies have documented that cortical atrophy proceeds similarly to neurofibrillary tangle pathology (Braak and Braak, 1991; Whitwell et al., 2008) and in vivo imaging studies have also reported similar distribution between cortical atrophy and tau retention in patients with typical and atypical AD (Xia et al., 2017; Nasrallah et al., 2018; Whitwell et al., 2018).