AD subtypes have been previously defined in studies using cortical atrophy in MRI (Shiino et al., 2006; Noh et al., 2014; Whitwell et al., 2018), postmortem neurofibrillary tangle counts (Murray et al., 2011), and tau retention in PET scans (Whitwell et al., 2018), but it has not been evaluated with in vivo multimodal imaging scans. Here, MAPT is linked to Alzheimer disease.