Interestingly, Angelman Syndrome is generally associated with UBE3A deletions, while ASD can be caused by duplications – yet the same individual can be diagnosed with both syndromes (Peters et al., 2004; Williams et al., 2010; Smith et al., 2011; Kalsner and Chamberlain, 2015; Yi et al., 2015). The gene discussed is UBE3A; the disease is Angelman syndrome.