Jensen et al. (2008), for example, proposed that its unique properties as a potent norepinephrine reuptake transporter and partial 5-HT1A might mediate quetiapine’s efficacy in depression, but also described medium- to high-affinity to muscarinic receptors as an antagonist, contrasting with quetiapine is this regard. This evidence concerns the gene HTR1A and major depressive disorder.