However, at the protein level, flow cytometry analyses performed after 4 injections of mAb revealed two-fold higher NOS2 expression in CD11c+ as well as F4/80+/Gr1− fractions of CD45+ tumor infiltrating cells from anti-PD-1-treated mice compared with isotype-treated controls (Fig. 5d). The gene discussed is PDCD1; the disease is neoplasm.