PDCD1 and colonic neoplasm: While the MCA205WT sarcoma remained sensitive to 4 doses of PD-1 blockade over 12 days (Fig. 1b; Supplementary information, Fig. S1b), hosts bearing MCA205OVA and MC38 colon cancers were eventually resistant as initial treatments slightly reduced their tumor growth kinetics (Fig. 1c; Supplementary information, Fig. S1a, c and e).