We then analyzed the regulation of NOS2 gene expression by type I IFN in peripheral blood mononuclear cells (PBMC) from eight healthy volunteers (HV) and four melanoma (MEL) patients (Supplementary information, Fig. S10a, upper panel) together with TILs from seven stage III/IV MEL patients (Supplementary information, Fig. S10a, lower panel). Here, NOS2 is linked to melorheostosis.