An immunoregulatory-rich tumor microenvironment was associated with lower mean of CD68+ pSTAT1+ cell numbers (mean 163 cells/mm2 for FOXP3+/GrB ratio >1.5 vs. mean 270 cells/mm2 for FOXP3+/GrB ratio ratio <1.5, p = 0.028, Mann-Whitney test). This evidence concerns the gene FOXP3 and neoplasm.