We hypothesised that microtubule disruption would inhibit TGF-β-induced expression of the breast cancer EMT-driving transcription factors Snail (SNAI1) and Slug (SNAI2) because a key mediator of their transcription, Smad2/3, is trafficked to the nucleus along microtubules.21 This evidence concerns the gene TGFB1 and breast carcinoma.