A similar subcompartmentalised CFTR activation has been proposed for an anti-colon cancer drug (irinotecan) and an anti-retroviral drug (3′-azido-3′-deoxythymidine) using intestinal fluid secretion in closed-loop diarrhoea model and enterospheres, isolated from wild-type (Mrp4+/+) and Mrp4−/− mice72. The gene discussed is ABCC4; the disease is Diarrhea.