However, individuals with GON7 mutations presented with milder neurological and renal manifestations, always with post-natal microcephaly and no gyration defects, later onset of proteinuria (median age 18 months vs. 1) and slower progression to ESRD (median age 49 months in 8/11 children vs. 5 months in 3/3 children), and a longer survival compared to the YRDC cases. Here, GON7 is linked to microcephaly.