LHB and major depressive disorder: Along the same line, the LHb, in particular via the mesohabenular pathway, has attracted significant attention due to its role in addiction, reward, aversion, anxiety and depression (Matsumoto and Hikosaka, 2007; Hikosaka et al., 2008; Namboodiri et al., 2016; Fakhoury, 2017; Mizumori and Baker, 2017; Yang et al., 2018b).