MOG and acute disseminated encephalomyelitis: Children with high affinity MOG Ab predominantly presented with ADEM (55%, 7/20 monophasic and relapsing ADEM, and 4/20 ADEM/ON), whereas adults with high affinity MOG Ab mainly had BON (30%, 8/26, monophasic and relapsing) followed by UON (24%, 6/26, monophasic and relapsing, Additional file 1: Figure S6E).