EGFR and neoplasm: During skin tumorigenesis, single and multiple applications of tumor promoter leads to the activation of the Ras/Raf/MAPK/ERK and PI3K/AKT/mTOR pathways [19, 37] In this study, once EGFR is activated by the tumor initiator (DMBA) it will phosphorylate the upper stream targets in PI3K/AKT/mTOR and Ras/Raf/MAPK pathways which in majorly consisted of kinases protein.