Others found variable percentages of cases in which the VSCC (> 30%) or VSCC-infiltrating immune cells (> 90%) expressed PD-L1 [11, 36, 37], congruent with our observation that there are varying numbers of tumor-infiltrating T cells which can produce IFN-γ, as indicated by expression of Tbet, and may lead to adaptive PD-L1 expression [38]. The gene discussed is TBX21; the disease is neoplasm.