BTK and systemic lupus erythematosus: To date, studies on the IFN-α-accelerated NZB/NZW F1 model have provided many new target molecules for SLE, such as miR-130b as a negative regulator in the IFN pathway [24], a Btk inhibitor as a B cell regulator [25] and Ox40 as a molecule involved in a novel pathogenic pathway of SLE [26].