Recently, an injection of an adenovirus expressing IFN-α (Adv-IFN-α) in 12- to 13-week-old NZB/W F1 mice was found to accelerate the main clinical symptoms of SLE, making IFN-α-accelerated NZB/NZW F1 mouse models a useful tool to explore the intricate pathogenesis of SLE [23]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.