They found that FOXP3 DNAm was significantly higher in association with higher average PAH concentrations over 1 month, 3 months, and 1 year in asthmatics, while in non-asthmatics, higher FOXP3 DNAm was only seen with average PAH concentrations over 3 months and a year. The gene discussed is FOXP3; the disease is pulmonary arterial hypertension.