They have manifested that circ-ITCH could act as a tumor suppressor in ESCC and an increase in circ-ITCH expression ITCH leaded to represses the Wnt/β-catenin pathway through the destruction of phosphorylated Dvl2 via sponge of miR-7, miR-17 and miR-214. This evidence concerns the gene ITCH and neoplasm.