SPP1 and renal cell carcinoma: In order to determine whether YBX1/G3BP1 complex could regulate downstream NF-κB signaling pathway via SPP1 in RCC cells, we first selected the most effective siRNAs against SPP1 (si-SPP1–1, si-SPP1–2, si-SPP1–3) in ACHN cells (Fig. 3d).