With evidence from our recent study showing that G3BP1 contributes to the metastasis of RCC in both in vitro assay and in vivo xenograft model [26], and others indicating that YBX1 and G3BP1 expression levels are highly correlated in human sarcomas [17], we examined whether YBX1 affects G3BP1 expression and cellular localization in RCC. The gene discussed is G3BP1; the disease is sarcoma.