UXT promotes the formation of PRC2 complex and increases EZH2 histone methyltransferase (HMTase) activity, which subsequently inhibits the expression of many tumor suppressor genes such as DAB2IP and HOXA9. Our data also showed that the expression of UXT was upregulated in ccRCC tissues compared with paracarcinoma tissues. Here, EZH2 is linked to nonpapillary renal cell carcinoma.