It was reported the agents that inhibited erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2), or vascular endothelial growth factor (VEGF), including Trastuzumab, Ramucirumab and Apatinib, could increase response and survival times of ESCC patients [2]. The gene discussed is VEGFA; the disease is esophageal squamous cell carcinoma.