RNASE2 and parasitic infectious disease: They contain numerous cationic proteins, with four being the most notable: major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin (EDN); they are mostly associated with parasitic infections, since they have the ability to orchestrate the immune response against helminths in a Th2 cytokine cascade, very similar to that in asthmatic patients with the Th2 endotype [6].