AR and major depressive disorder: Immunoreactivity of AR has been reported to localize mainly in hippocampal CA1 pyramidal neurons and scarcely in CA3 and dentate gyrus neurons [36], brain regions that show shrinkage in patients with MDD [53] and chronic stress can suppress neuronal function, especially synaptic plasticity in CA1 and CA3 areas of the hippocampus in rats [54,55].