Depression (BDI, BSI), stress (PSS), hope (SHS), gratitude (SG), quality of life (SF-36), spirituality (ISWBS), personal transformation (TCQ), physical activity (PPAQ),stress (HR, BP, BMI, lipid levels, lipid particle size, high sensitivity C-reactive protein, biomarkers IL-6 and IL-10). The gene discussed is IL6; the disease is major depressive disorder.