The predicted mean cell count by the ERDCNN in the AKTP-P2rx7 group (24.26) was lower than that in the AKTP group (29.69), suggesting that P2rx7 over-expression induced the EMT phenotype in the malignant colorectal cancer organoids and the EMT phenotype inhibited the cell growth of those organoids. Here, P2RX7 is linked to colorectal cancer.