Unexpectedly, their results indicated that the mutant model of TP53 deletion and Brca2 inactivation promoted pancreatic cancer development, but the mouse model of KrasG12D combined with BRCA2 inactivation caused chromosomal instability and cell apoptosis, and resulted in the inhibition of tumors growth [167]. The gene discussed is BRCA2; the disease is pancreatic neoplasm.