TP53 and familial pancreatic carcinoma: From our previous study, attempting to study the deletion of APC in the pancreas, we observed that APC haploinsufficiency corresponded with KrasG12D mutation and P53 loss in mice, leading to rapidly increased development of metastatic PDAC when compared with Pdx1-cre, KrasG12D, P53Lox/+ mice That evidence indicated a critical tumor suppressor role of APC in pancreatic cancer progression [139].