Recently, we demonstrated the potential tumor-suppressing function of KLF10 in the progression of pancreatic cancer, via employing two well-characterized Pdx-1 Cre, LSL-KrasG12D and Pdx-1Cre, LSL-KrasG12D, p53Lox/Lox PDAC models, combined with KLF10 loss to dissect the molecular mechanism underlying KLF10 loss on pancreatic tumor development and progression [118]. The gene discussed is PDX1; the disease is familial pancreatic carcinoma.