Apigenin was demonstrated to be a new inhibitor of AKT in lung cancer suppressing phosphorylation of Akt and inhibited the gene expression of MMP-9 (matrix metalloproteinases-9), GSK-3 (glycogen synthase kinase-3β), and HEF1 (human enhancer of filamentation 1) [31]. Here, MMP9 is linked to lung cancer.