TP53 and lung cancer: A considerable number of genomic studies associate lung cancer with TP53 (tumor protein 53), PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PI3K/Akt (phosphatidylinositol-3-kinase) mutations [6], RTK alteration (receptor of tyrosine kinase like EGFR (epidermal growth factor receptor), MET, ROS1 (reactive oxygen species), ALK (anaplastic lymphoma kinase) and RET (proto-oncogene tyrosine-protein kinase receptor) [7].