It is well-documented that RET/PTC1 is the predominant type of gene rearrangements in the pediatric PTC [64,65,66,67], and that the frequency of sporadic thyroid cancer cases harboring the RET/PTC rearrangements decreases with age, while those with the BRAF mutation becomes more common [20]. The gene discussed is CCDC6; the disease is thyroid gland carcinoma.