In summary, Ang-II induced cardiac hypertrophy responses to involve partial contribution through increased β-catenin expression which, in turn, upregulate IGF-IIR expression via a consensus TCF/LEF1 binding sequence on IGF-IIR promoter and, thereafter, IGF-IIR signaling activates the downstream cardiac hypertrophy cascade. This evidence concerns the gene AGT and cardiac hypertrophy.