APOE and cardiovascular disorder: The apolipoprotein (APO) E (ε) genotype is the most widely researched single nucleotide polymorphism in relation to cardiovascular disease (CVD) risk, with the APOE4 allele linked with increased total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), CVD risk and mortality [1,2,3,4,5].