In our results, the induction of the mRNA levels of adiponectin, FgfR1, FgfR4 and Egr1 in scWAT of HFDM mice indicates that, in obesity, maqui supplementation increases the sensitivity to FGF21 of scWAT. The gene discussed is FGFR4; the disease is obesity due to melanocortin 4 receptor deficiency.