INS and obesity due to melanocortin 4 receptor deficiency: Besides its antioxidant activity, different preparations of maqui have shown positive effects on fasting glucose and insulin levels in humans and murine model of type 2 diabetes and obesity [34,35,36,37] and delphinidin-3-sambubioside-5-glucoside has been described as the responsible for hypoglycemic activity in in vivo models [36].