In terms of the study population, there were exclusions for pregnancy, and type 1 diabetes mellitus and for subjects with serum CRP ≥10 mg/L (to minimize confounding effects by acute inflammation, rheumatic or other disease conditions manifesting high levels of inflammation); while it should also be noted that the study cohort was almost exclusively comprised of subjects of white European origin thus potentially limiting relevance of study findings to other populations. This evidence concerns the gene CRP and diabetes mellitus.