Furthermore, results of a clinical study of metabolic syndrome (MetS) showed that although subjects without MetS demonstrated a positive correlation of PON1 activity with serum apoE levels, suggestive of enhancement of PON1 anti-atherogenic action with increased apoE levels; the relationship was abrogated in subjects with MetS, a condition associated with inflammation and oxidative stress [34]. The gene discussed is PON1; the disease is metabolic syndrome.