For HR2, PON1 activity was highly significant (protective) in an unadjusted model (p = 10−6); continued to be highly significant in a collection of models adjusted for gender, age, and a set of covariates added one-at-time; and finally remained significant (p = 0.0003) in a model adjusted simultaneously for all covariates of the dataset (gender, age, UAE, past CVD, DM, apoB, use of statins, anti-hypertensives, smoking, ethanol use, and eGFR). This evidence concerns the gene APOB and diabetes mellitus.