The expression of LPL, PPAR-α, CYP7A1, and CPT1 in liver tissue was significantly decreased (p < 0.05), while the expression of PPAR-γ and C/EBP-α was significantly increased (p < 0.05) in mice induced by NAFLD. Here, CYP7A1 is linked to metabolic dysfunction-associated steatotic liver disease.