The serum levels of cytokines IL-1β, IL-4, IL-6, IL-10, TNF-α, and INF-γin NAFLD mice (the model group) were significantly lower than those in mice of the model group without non-intervention (p < 0.05), and RBTP-H had the strongest action to decrease these cytokines, which was significantly stronger than the drug bezafibrate. This evidence concerns the gene IL4 and metabolic dysfunction-associated steatotic liver disease.