Stratified by IBD subtype, both CD and UC patients with severe disease activity exhibited significantly reduced levels of albumin-adjusted serum free thiols compared to patients with mild disease activity (CD, 16.6 ± 0.8 μmol/g vs. 20.0 ± 2.3 μmol/g, P < 0.05; UC, 16.2 ± 3.4 μmol/g vs. 20.8 ± 4.7 μmol/g, P < 0.05) (Figure 2B,C). This evidence concerns the gene ALB and inflammatory bowel disease.